Li, Xue-Hong; Gong, Jun-Fang; Song, Mao-Ping published an article in 2021. The article was titled 《Diastereoselective synthesis of chiral 3-substituted isoindolinones via rhodium(III)-catalyzed oxidative C-H olefination/annulation》, and you may find the article in Organic & Biomolecular Chemistry.Formula: C8H7FO2 The information in the text is summarized as follows:
A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(III)-catalyzed chiral N-sulfinyl amide directed asym. [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramol. aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. The absolute configurations of the newly formed C-stereocenters in the major and minor diastereomers of the catalysis product have been determined by X-ray crystal diffraction anal. to be S and R, resp. The separation of the major diastereoisomers from the catalysis products and subsequent removal of the N-sulfinyl chiral auxiliary afforded enantiomerically pure (S)-isoindolinones. The application of the obtained (S)-isoindolinones in the synthesis of several biol. active isoindolinones such as (S)-PD172938, (S)-pazinaclone and (S)-pagoclone is presented. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Formula: C8H7FO2) was used in this study.
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Formula: C8H7FO2
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