K. Pagire, Santosh; Kumagai, Naoya; Shibasaki, Masakatsu published the artcile< Highly Enantio- and Diastereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes from α,β-Unsaturated Amides and Stabilized Sulfur Ylides Catalyzed by a Chiral Copper(I) Complex>, COA of Formula: C19H34O2, the main research area is cyclopropane preparation enantioselective diastereoselective; amide sulfur ylide cyclization copper catalyst.
Herein, the previously elusive catalytic asym. cyclopropanation of α,β-unsaturated amides, e.g., (E)-3-(but-2-enoyl)oxazolidin-2-one with stabilized sulfur ylides RC(O)CH=S(Me)2 has been efficiently accomplished utilizing a chiral Cu(I) complex. This Lewis acid catalytic system effectively converts a wide range of electron-deficient alkenes into the corresponding 1,2,3-trisubstituted cyclopropanes, e.g., I under mild reaction conditions in good to excellent yields with both high to excellent enantio- and diastereoselectivities. The resulting enantiomerically enriched cyclopropane amides can be readily diversified into promising synthetic intermediates such as β-aminocyclopropanecarboxylic acids with the facile recovery of the 7-azaindoline auxiliary without influencing the optical purity of the cyclopropane unit, which highlights the synthetic efficacy of this catalytic approach.
ACS Catalysis published new progress about Carboxylic acids Role: FMU (Formation, Unclassified), FORM (Formation, Nonpreparative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics