Gupta, Aniket; Saha, Anusuya; Rahaman, Ajijur; Kumar, Jogendra; Suresh, Eringathodi; Ganguly, Bishwajit; Bhadra, Sukalyan published their research in Journal of Organic Chemistry on August 5 ,2022. The article was titled 《Cooperativity between the Substrate and Ligand in Palladium-Catalyzed Allylic Alkylation Using 1-Aryl-1-propynes》.Safety of Methyl 3-oxovalerate The article contains the following contents:
A monoprotected amino acid Bz-Gly-OH assists in the allylic alkylation of a variety of ketones, β-keto esters, aldehydes, etc., during enamine-palladium catalysis to gave alkylated products such as R1C(O)CHR2CH2CH=CHAr [R1 = Me, Et, n-Pr; R2 = Et, C(O)OMe, C(O)OEt, C(O)OBn, etc.; R1R2 = (CH2)3, (CH2)4, (CH2)5, etc.]. D. functional theory calculations revealed that Bz-Gly-OH assisted in the formation of an enamine that attacks the π-allylpalladium complex via an outer sphere mechanism. The preliminary result pointed to an asym. allylic alkylation under a new mode of bifunctional catalysis. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Safety of Methyl 3-oxovalerate)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Safety of Methyl 3-oxovalerate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics