Fares, Mohamed; Canfield, Peter; Alsherbiny, Muhammad A.; Lewis, William; Willis, Anthony C.; Guang Li, Chun; Neyts, Johan; Jochmans, Dirk; Gale, Philip A.; Keller, Paul A. published an article in 2022. The article was titled 《Synthesis, X-ray crystallographic analysis, DFT studies and biological evaluation of triazolopyrimidines and 2-anilinopyrimidines》, and you may find the article in Journal of Molecular Structure.Recommanded Product: 4949-44-4 The information in the text is summarized as follows:
Inspired by the reported antiviral activity of pyrimidines and triazolopyrimidines, two series of 2-anilinopyrimidines I (R1 = H, 3-F, 3-Cl-4-CF3 etc.) and 1-aryl-[1,2,4]triazolo[4,3-a]pyrimidines II (R2 = COMe, CO2Et; Ar = 3-FC6H4, 3-CH3COC6H4, 3-iPrOPh, etc.) were designed and synthesized as potential antiviral agents. The pharmacokinetic properties and calculation of drug likeness scores (DLS) of I and II suggested good traditional drug-like properties and led to the synthesis of derivatives II which were evaluated for their anti-viral activity with the most potent derivatives subjected to cytotoxicity screening. Compounds II (R2 = COMe; Ar = 3-FC6H4) II (R2 = COMe; Ar = 3-CH3COC6H4), II (R2 = COMe; Ar = 3-iPrOPh), II (R2 = CO2Et; Ar = 3-iPrOPh) and II (R2 = COMe; Ar = 4-BrPh) showed moderate to strong antiviral activity with EC50 values 38 – 186μM. Compound I (DLS = 0.29) showed the best anti-CHIKV activity (EC50 = 38μM) and lowest cytotoxicity (CC50 > 300μg/mL) against breast cancer cell lines, MCF-7 and MD-AMB-231 and normal cell line EA.hy926. Simplification of [1,2,4]triazolo[4,3-a]pyrimidine ring, led to series I (DLS = 0.03 – 0.77). Derivatives I showed fair anti-CHIKV activity (EC50 > 200μM), while I (R1 = 3-Cl-4-CF3) emerged as the most active antiviral agent, however the most cytotoxic. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: 4949-44-4)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: 4949-44-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics