Ahmed, Moinuddin Md.; Mortensen, Matthew S.; O’Doherty, George A. published the artcile< De Novo Synthesis of 2-Substituted syn-1,3-Diols via an Iterative Asymmetric Hydration Strategy>, Electric Literature of 112-63-0, the main research area is ester dihydroxy benzylidene protected asym synthesis; dienoate enantioselective regioselective Sharpless dihydroxylation; carbonate cyclic asym synthesis stereoselective reduction palladium catalyst; unsaturated ester hydroxy asym synthesis diastereoselective hydration.
The enantioselective syntheses of several protected 4-substituted syn-3,5-dihydroxy carboxylic esters have been achieved from the corresponding achiral (E,E)- or (E,Z)-1,3-dienoates. The route relies upon an enantio- and regioselective Sharpless dihydroxylation and a palladium-catalyzed reduction to form γ-substituted δ-hydroxy-1-enoates. The resulting δ-hydroxy-1-enoates are subsequently converted into benzylidene-protected 4-substituted syn-3,5-dihydroxy carboxylic esters in one step. The benzylidene-protected 3,5-dihydroxy carboxylic esters are produced in good overall yields (20-54%) and high enantiomeric excess (73-97% ee).
Journal of Organic Chemistry published new progress about Carbonates Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics