Abdel-Maksoud, Mohammed S.; Ali, Eslam M. H.; Ammar, Usama M.; Mersal, Karim I.; Yoo, Kyung Ho; Oh, Chang-Hyun published the artcile< Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF>, Synthetic Route of 34637-22-4, the main research area is cancer anticancer BRAF inhibitors kinase inhibitor SAR; Anticancer; B-RAF inhibitors; Kinase inhibitor; Pyrrolo[2,3-b]pyridine; SAR.
Several pyrrolo[2,3-b]pyridine-based B-RAF inhibitors are well known and some of them are currently FDA approved as anticancer agents. Based on the structure of these FDA approved V600EB-RAF inhibitors, two series of pyrrolo[2,3-b]pyridine scaffold were designed and synthesized in attempt to develop new potent V600EB-RAF inhibitors. The 38 synthesized compounds were biol. evaluated for their V600EB-RAF inhibitory effect at single dose (10 μM). Compounds with high percent inhibition were tested to determine their IC50 over V600EB-RAF. Compounds 34e and 35 showed the highest inhibitory effect with IC50 values of 0.085 μM and 0.080 μM, resp. Headed for excessive biol. evaluation, the synthesized derivatives were tested over sixty diverse human cancer cell lines. Only compound 35(I) emerged as a potent cytotoxic agent against different panel of human cancer cell lines.
Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Synthetic Route of 34637-22-4.
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Ester – an overview | ScienceDirect Topics