The author of 《Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines》 were Yu, Lu; Somfai, Peter. And the article was published in Angewandte Chemie, International Edition in 2019. COA of Formula: C7H13NO2 The author mentioned the following in the article:
The asym. formal hydroamination of enamines using a CuH catalyst is reported [e.g., enamine I + O-acylhydroxylamine II → diamine III (69%, 97:3 e.r.) in presence of (MeO)2MeSiH as hydride source, Cu(OAc)2 and (R)-DTBM-SEGPHOS]. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of mols. bearing a 1,2-diamine motif.Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2COA of Formula: C7H13NO2) was used in this study.
Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.COA of Formula: C7H13NO2
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