Yayik, Nihan; Perez, Maria; Molins, Elies; Bosch, Joan; Amat, Mercedes published the artcile< Studies on the enantioselective synthesis of E-ethylidene-bearing spiro[indolizidine-1,3'-oxindole] alkaloids>, Quality Control of 112-63-0, the main research area is ethylidene bearing spiro indolizidine oxindole alkaloid enantioselective preparation; alkaloids; ethylidene; oxindoles; spiro compounds.
A synthetic route for the enantioselective construction of the tetracyclic spiro[indolizidine-1,3′-oxindole] framework present in a large number of oxindole alkaloids, with a cis H-3/H-15 stereochem., a functionalized two-carbon substituent at C-15, and an E-ethylidene substituent at C-20, was reported. The key steps of the synthesis were the generation of the tetracyclic spirooxindole ring system by stereoselective spirocyclization from a tryptophanol-derived oxazolopiperidone lactam, the removal of the hydroxymethyl group, and the stereoselective introduction of the E-ethylidene substituent by acetylation at the α-position of the lactam carbonyl, followed by hydride reduction and elimination. Following this route, the 21-oxo derivative of the enantiomer of the alkaloid 7(S)-geissoschizol oxindole was prepared
Molecules published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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