Vodicka, Petr; Streinz, Ludvik; Vavra, Jan; Koutek, Bohumir; Budesinsky, Milos; Ondracek, Jan; Cisarova, Ivana published the artcile< Synthesis of (R)- and (S)-3,3,3-trifluoro-2-phenylpropanoyl isocyanates and their use as reactive analogues of Mosher's acid>, SDS of cas: 617-55-0, the main research area is isocyanate trifluorophenylpropanoyl Mosher preparation alc addition; carbamate preparation.
The title isocyanates have been prepared from the resp. 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acids (MTPA) by a three-step synthesis with MTPA chloride and MTPA amide as reaction intermediates. The requested compounds were obtained in high chem. yields without any change in optical purity during the preparation To ascertain the usefulness of this auxiliary agent in the chiral anal., both 3,3,3-trifluoro-2-phenylpropanoyl isocyanates were subjected in NMR tubes to non-catalyzed reactions with 16 different com. available chiral alcs. The steric arrangement of all diastereomers prepared correlated well with their NMR spectral nonequivalence data (Δδ), thus demonstrating the regular sign distribution of Δδ of particular groups according to the devised mol. model.
Chirality published new progress about Alcohols, chiral Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.
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