Townes, Jennifer A.; Evans, Michael A.; Queffelec, Jerome; Taylor, Steven J.; Morken, James P. published the artcile< Stereoselective Synthesis of trans β-Lactams through Iridium-Catalyzed Reductive Coupling of Imines and Acrylates>, Recommanded Product: Perfluorophenyl acrylate, the main research area is beta lactam stereoselective synthesis iridium catalyst; reductive coupling iridium catalyst beta lactam stereoselective synthesis; acrylate reductive coupling imine iridium catalyst; crystal mol structure methoxyphenylmethylnaphthylazetidinone; azetidinone stereoselective synthesis iridium catalyst; substituent effect reductive coupling imine acrylate iridium catalyst.
Iridium-catalyzed reductive coupling of acrylates and imines provides trans β-lactams with high diastereoselection. The optimal catalyst allows for the synthesis of trans β-lactams bearing aromatic, alkenyl, and alkynyl side chains. This reaction appears to proceed through a reductive Mannich addition-cyclization mechanism. Examination of substituent effects reveals a linear Hammett correlation for both the N-aryl group on the imine and the aryloxy group on the acrylate, thereby pointing to rate-determining cyclization in the reaction mechanism.
Organic Letters published new progress about Crystal structure. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.
Referemce:
Ester – Wikipedia,
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