In 2022,Sadhu, Milon M.; Ray, Sumit K.; Unhale, Rajshekhar A.; Singh, Vinod K. published an article in Organic & Biomolecular Chemistry. The title of the article was 《Bronsted acid-catalyzed enantioselective addition of 1,3-diones to in situ generated N-acyl ketimines》.Formula: C8H7FO2 The author mentioned the following in the article:
A Bronsted acid-catalyzed asym. Mannich-type addition of 1,3-diones to cyclic N-acyl ketimines is reported for the synthesis of enantioenriched isoindolinones. Various dicarbonyl-substituted isoindolinones bearing a quaternary carbon stereocenter were synthesized with excellent yields (up to 98%) and moderate to high enantioselectivities (up to 95% ee), and most of them possess a fluorine atom at the reactive center. Furthermore, the synthetic utility of the protocol has been demonstrated by the debenzoylation of the product. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Formula: C8H7FO2)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Formula: C8H7FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics