Rachwalak, Marta; Rozniewska, Malgorzata; Golebiewska, Justyna; Jakubowski, Tomasz; Sobkowski, Michal; Romanowska, Joanna published the artcile< A practical synthesis of nucleoside 5'-diphosphates from nucleoside 5'-H-phosphonate monoesters>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nucleotide nucleoside phosphate phosphonate synthesis pyridinium oxidation deoxyribonucleoside.
A simple and convenient synthetic protocols based on H-phosphonate chem. have been developed for the preparation of nucleoside 5′-diphosphates. It consists of oxidation of the silylated H-phosphonate monoesters in pyridine with iodine to produce the corresponding N-pyridinium phosphonate intermediates, followed by their reactions with orthophosphoric acid used as a nucleophile. The added value of the method is that substrates for the reaction, H-phosphonate monoesters, can be prepared in situ from the corresponding nucleosides and used for the next step without isolation. The procedure is simple and applicable to the preparation of various diphosphates of ribo- and deoxyribonucleosides, and their analogs.
Synthetic Communications published new progress about Deoxyribonucleosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics