Min, Qing-Qiang; Li, Na; Chen, Guang-Le; Liu, Feng published the artcile< Copper-catalysed C(sp3)-N coupling initiated by selective C-C bond cleavage of cyclobutanone oxime esters>, Category: esters-buliding-blocks, the main research area is arylaminobutanenitrile preparation chemoselective; cyclobutanone oxime ester aryl amine bond cleavage amination copper.
Herein, an efficient copper-catalyzed selective C-C bond cleavage/amination of cyclobutanone oxime esters is reported. This reaction protocol is operationally simple and conducted at ambient temperature, allowing access to a wide range of functionalized 4-(arylamino)butanenitriles in moderate to excellent yields. This transformation shows high chemo-selectivity and wide functional-group compatibility and can be easily scaled up to the gram level with a useful yield. A mechanism involving copper-catalyzed capture of alkyl radical intermediates by amine nucleophiles is proposed.
Organic Chemistry Frontiers published new progress about Amination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics