Cain, Gary A.; Christos, Thomas E.; Johnson, Alexander L.; Pottorf, Richard S.; Confalone, Pat N.; Tam, S. William; Schmidt, William K. published the artcile< Neurotensin receptor binding and antinociceptive activity for lipophilic Nα-amido neurotensin(9-13) analogs>, Synthetic Route of 112-63-0, the main research area is lipophilic acyl neurotensin pentapeptide analog; receptor neurotensin binding pentapeptide analog; antinociceptive lipophilic acyl neurotensin pentapeptide analog.
Lipophilic Nα-acyl neurotensin(9-13) analogs RCO-X-Pro-Tyr-Ile-Leu-OH [RCO = Me3CO2C (Boc), Ac, Bz, tert-BuCO, tert-BuCH2CO, 1-AdCO, n-C7H15CO, n-C17H35CO, bicyclo[2.2.1]heptane-2-acetyl, bicyclo[3.3.0]octane-2-carbonyl, biotinyl, 4-tert-BuPhCO, 3-pyridylcarbonyl, 4-PhC6H4CO, X = Lys; RCO = Boc, 1-AdCO, X = Orn] were prepared These acylated pentapeptides exhibited good neurotensin receptor binding, as well as in vivo analgesic activity via i.c.v. and even i.v. routes of administration.
Bioorganic & Medicinal Chemistry Letters published new progress about Analgesics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics