Buck, Jason R.; Saleh, Sam; Imam Uddin, Md.; Manning, H. Charles published the artcile< Rapid, microwave-assisted organic synthesis of selective V600EBRAF inhibitors for preclinical cancer research>, Electric Literature of 112-63-0, the main research area is azaindole PLX4720 PLX4032 preparation BRAF inhibitor microwave irradiation.
We report dramatically improved total syntheses of two highly selective V600EBRAF inhibitors, PLX4720 and PLX4032, that leverages microwave-assisted organic synthesis (MAOS). Compared with previously reported approaches, our novel MAOS method significantly reduces overall reaction time without compromising yield. In addition to providing a gram-scale route to these compounds for preclin. oncol. research, we anticipate this approach could accelerate the synthesis of azaindoles in high-throughput, library-based formats.
Tetrahedron Letters published new progress about Microwave irradiation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics