《Ligand-controlled divergent dehydrogenative reactions of carboxylic acids via C-H activation》 was written by Wang, Zhen; Hu, Liang; Chekshin, Nikita; Zhuang, Zhe; Qian, Shaoqun; Qiao, Jennifer X.; Yu, Jin-Quan. Quality Control of Benzyl acrylateThis research focused onunsaturated carboxylic acid alkylidene butenolide preparation chemoselective; carboxylic acid dehydrogenation palladium pyridine pyridone ligand catalyst. The article conveys some information:
Dehydrogenative transformations of alkyl chains to alkenes through methylene carbon-hydrogen (C-H) activation remain a substantial challenge. Two classes of pyridine-pyridone ligands that enable divergent dehydrogenation reactions through palladium-catalyzed β-methylene C-H activation of carboxylic acids, leading to the direct syntheses of α,β-unsaturated carboxylic acids or γ-alkylidene butenolides have been reported. The directed nature of this pair of reactions allows chemoselective dehydrogenation of carboxylic acids in the presence of other enolizable functionalities such as ketones, providing chemoselectivity that is not possible by means of existing carbonyl desaturation protocols. Product inhibition is overcome through ligand-promoted preferential activation of C(sp3)-H bonds rather than C(sp2)-H bonds or a sequence of dehydrogenation and vinyl C-H alkynylation. The dehydrogenation reaction is compatible with mol. oxygen as the terminal oxidant. The experimental process involved the reaction of Benzyl acrylate(cas: 2495-35-4Quality Control of Benzyl acrylate)
Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Quality Control of Benzyl acrylate
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