Liu, Xigong; Zhao, Changyin; Zhu, Rongxiu; Liu, Lei published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition》.Reference of Ethyl 2-methyl-3-oxobutanoate The article contains the following contents:
The asym. construction of vicinal quaternary carbon stereocenters with at least one moiety in acyclic systems is a formidable challenge. A solution involving diastereo- and enantioselective oxidative 1,6-conjugate addn was disclosed. The practical asym. cross-dehydrogenative coupling of 2,2-diarylacetonitriles and diverse α-substituted cyclic 1,3-dicarbonyls proceeds, for vicinal quaternary carbon stereocenters with one center in acyclic systems, in excellent yields and stereoselectivities. The generality of the approach was further demonstrated by the stereoselective creation of vicinal quaternary carbon stereocenters with both centers in acyclic systems using acyclic β-ketoesters as coupling partners. Computational studies elucidate the origins of both diastereo- and enantioselectivity. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Reference of Ethyl 2-methyl-3-oxobutanoate)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Reference of Ethyl 2-methyl-3-oxobutanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics