COA of Formula: C6H10O3On September 5, 2021 ,《Rational design, synthesis, biological evaluation and molecular docking studies of chromone-pyrimidine derivatives as potent anti-cancer agents》 was published in Journal of Molecular Structure. The article was written by Kantankar, Abhijit; Jayaprakash Rao, Y.; Mallikarjun, G.; Hemasri, Y.; Kethiri, Raghava Reddy. The article contains the following contents:
A series of pyrimidine based chromone hybrids I [R = Me, methoxymethyl, 4-fluorophenyl, etc.; R1 = H, methoxycarbonyl, ethoxycarbonyl, etc.] were synthesized from 7-methoxy-8-formyl-chromone using facile multi-component modified Biginelli reaction. All the synthesized compounds I were characterized and evaluated for their in-vitro anti-cancer activity against three cancer cell lines, human cervical (HeLa), lung (A549), myelogenous leukemia (K562) cancer cell lines and on a normal cell line(HEK-293) for the selectivity reference Among them, compounds I [R = 4-fluorophenyl, 2-fluorophenyl, 4-methoxyphenyl, 4-(trifluoromethoxy)phenyl; R1 = H] and I [R = methoxymethyl, methyl; R1 = methoxycarbonyl, ethoxycarbonyl] exhibited potent anti-cancer activities against A549, HeLa and K562 cell lines with IC50 values in micro molar range. The compounds I were displayed selective anti-cancer activity against K562 cell line compared to on other cancer cell lines. All the compounds I showed relative non-toxicity against normal cell line. The selectivity of the compounds against K562 cell line has been substantiated by mol. docking in BCR-ABL Tyrosine kinase using genetic algorithm program (GOLD 3.0.1). These results indicated that the chromones I were promised as the anti-cancer agents for the effective treatment of different types of cancers. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-oxovalerate(cas: 30414-53-0COA of Formula: C6H10O3)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.COA of Formula: C6H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics