Gao, Xin; Turek-Herman, Joshua R.; Choi, Young Joo; Cohen, Ryan D.; Hyster, Todd K. published their research in Journal of the American Chemical Society on December 1 ,2021. The article was titled 《Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “”Ene””-Reductases》.Recommanded Product: 30414-53-0 The article contains the following contents:
α-Tertiary amines are a common motif in pharmaceutically important mols. but are challenging to prepare using asym. catalysis. Here, author demonstrate engineered flavin-dependent ‘ene’-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated charge-transfer complex formed between the substrate and cofactor. These products can be further derivatized to prepare a variety of motifs, highlighting the versatility of ERED photoenzymic catalysis for organic synthesis. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-oxovalerate(cas: 30414-53-0Recommanded Product: 30414-53-0)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Recommanded Product: 30414-53-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics