Choi, Jin; Laudadio, Gabriele; Godineau, Edouard; Baran, Phil S. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Practical and Regioselective Synthesis of C-4-Alkylated Pyridines》.Application of 36016-38-3 The article contains the following contents:
The direct position-selective C-4 alkylation of pyridines has been a long-standing challenge in heterocyclic chem., particularly from pyridine itself. Historically this has been addressed using prefunctionalized materials to avoid overalkylation and mixtures of regioisomers. This study reports the invention of a simple maleate-derived blocking group for pyridines that enables exquisite control for Minisci-type decarboxylative alkylation at C-4 that allows for inexpensive access to these valuable building blocks. The method is employed on a variety of different pyridines and carboxylic acid alkyl donors, is operationally simple and scalable, and is applied to access known structures in a rapid and inexpensive fashion. Finally, this work points to an interesting strategic departure for the use of Minisci chem. at the earliest possible stage (native pyridine) rather than current dogma that almost exclusively employs Minisci chem. as a late-stage functionalization technique. In the part of experimental materials, we found many familiar compounds, such as N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Application of 36016-38-3)
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Application of 36016-38-3
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