Chen, Ming; Wu, Zheng-Jian; Song, Jinshuai; Xu, Hai-Chao published an article in 2022. The article was titled 《Electrocatalytic Allylic C-H Alkylation Enabled by a Dual-Function Cobalt Catalyst》, and you may find the article in Angewandte Chemie, International Edition.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate The information in the text is summarized as follows:
An electrocatalytic allylic C-H alkylation reaction with carbon nucleophiles RCH(R1)(C(O)R2) (R = H, F, Me, Bn, etc. ; R1 = H, CN, Me, Et; R2 = Me, OEt, pyrrolidin-1-yl, etc.) employing an easily available cobalt-salen complex as the mol. catalyst was reported. These C(3)-H/C(sp3)-H cross-coupling reactions proceed through H2 evolution and require no external chem. oxidants. Importantly, the mild conditions and unique electrocatalytic radical process ensure excellent functional group tolerance and substrate compatibility with both linear and branched terminal alkenes e.g., (hex-5-en-1-yloxy)benzene. The synthetic utility of the electrochem. method is highlighted by its scalability (up to 200 mmol scale) under low loading of electrolyte (down to 0.05 equiv) and its successful application in the late-stage functionalization of complex structures. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics