《Sterically Controlled C-H Olefination of Heteroarenes》 was written by Chen, Hao; Farizyan, Mirxan; Ghiringhelli, Francesca; van Gemmeren, Manuel. Electric Literature of C10H10O2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:
The regioselective functionalization of heteroarenes is a highly attractive synthetic target due to the prevalence of multiply substituted heteroarenes in nature and bioactive compounds Some substitution patterns remain challenging: While highly efficient methods for the C2-selective olefination of 3-substituted five-membered heteroarenes are reported, analogous methods to access the 5-olefinated products have remained limited by poor regioselectivities and/or the requirement to use an excess of the valuable heteroarene starting material. Herein the authors report a sterically controlled C-H olefination using heteroarenes as the limiting reagent. The method enables the highly C5-selective olefination of a wide range of heteroarenes and is useful in the context of late-stage functionalization. The results came from multiple reactions, including the reaction of Benzyl acrylate(cas: 2495-35-4Electric Literature of C10H10O2)
Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Electric Literature of C10H10O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics