Zosangpuii, Christina; Datta, Swagata; Gunindro, Ngangom; Meena, Dn; Nameirakpam, Surjit Singh published the artcile< Adverse drug reaction patterns of anti-retroviral drugs: a study in a tertiary care teaching institute of North East India>, Category: esters-buliding-blocks, the main research area is antiretroviral therapy adverse drug reaction pharmacovigilance age gender.
The use of antiretroviral drugs is associated with significant safety concerns but there is still insufficient data about the toxicity profile of antiretroviral therapy (ART) drugs especially in developing countries. Hence, this study was done to describe the severity and pattern of different types of adverse drug reactions that occurs with ART. A retrospective cross-sectional study was done at Pharmacovigilance center Regional Institute of Medical Sciences utilizing data from Jan. 2016 to Dec. 2019. A total of 190 cases reported during the study period were included in this study. Incidence was higher in females (109) as compared to males (81). The most common regimen responsible was Tenofovir/Lamivudine/Efavirenz (TLE) (69.5%) followed by Zidovudine/Lamivudine/Nevirapine (ZLN) (16.3%). Involvement of dermatol. system (27.4%) was most common. The most common Adverse drug reaction (ADR) associated with TLE was skin rash (28.3%) which was less severe as compared to the most common ADR associated with ZLN, which was anemia (40.6%). On evaluation of the World Health Organization-Uppsala Monitoring Center causality of ADRs, majority were found to be possible (78.2%). TLE regimen requires special focus as it was the most common regimen causing ADR but patients on ZLN regimen need to be closely monitored as they were found to cause more serious ADRs. A more active pharmacovigilance is needed for better understanding of toxicities related to ART.
Asian Journal of Pharmaceutical and Clinical Research published new progress about Anemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics