Zhao, Haoyang; Jin, Kangyu; Jiang, Chaonan; Pan, Fen; Wu, Jing; Luan, Honglin; Zhao, Zhiyong; Chen, Jingkai; Mou, Tingting; Wang, Zheng; Lu, Jing; Lu, Shaojia; Hu, Shaohua; Xu, Yi; Huang, Manli published the artcile< A pilot exploration of multi-omics research of gut microbiome in major depressive disorders>, Reference of 112-63-0, the main research area is major depressive disorder gut microbiome metabolism immunity brain.
The pathophysiol. of major depressive disorder (MDD) remains obscure. Recently, the microbiota-gut-brain (MGB) axiss role in MDD has an increasing attention. However, the specific mechanism of the multi-level effects of gut microbiota on host metabolism, immunity, and brain structure is unclear. Multi-omics approaches based on the anal. of different body fluids and tissues using a variety of anal. platforms have the potential to provide a deeper understanding of MGB axis disorders. Therefore, the data of metagenomics, metabolomic, inflammatory factors, and MRI scanning are collected from the two groups including 24 drug-naive MDD patients and 26 healthy controls (HCs). Then, the correlation anal. is performed in all omics. The results confirmed that there are many markedly altered differences, such as elevated Actinobacteria abundance, plasma IL-1β concentration, lipid, vitamin, and carbohydrate metabolism disorder, and diminished gray matter volume (GMV) of inferior frontal gyrus (IFG) in the MDD patients. Notably, three kinds of discriminative bacteria, Ruminococcus bromii, Lactococcus chungangensis, and Streptococcus gallolyticus have an extensive correlation with metabolome, immunol., GMV, and clin. symptoms. All three microbiota are closely related to IL-1β and lipids (as an example, phosphoethanolamine (PEA)). Besides, Lactococcus chungangensis is neg. related to the GMV of left IFG. Overall, this study demonstrate that the effects of gut microbiome exert in MDD is multifactorial.
Translational Psychiatry published new progress about Acrobacter (lekithochrous). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
Referemce:
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