Zhang, Hong-Yu; Yang, Zibing; Zhang, Huizhen; Han, Ya-Ping; Zhao, Jiquan; Zhang, Yuecheng published their research in European Journal of Organic Chemistry in 2021. The article was titled 《The Cross-Dehydrogenative Coupling Reaction of β-Ketoesters with Quinoxalin-2(1H)-ones》.Quality Control of Ethyl 3-oxopentanoate The article contains the following contents:
The cross-dehydrogenative coupling (CDC) reaction of β-ketoesters with quinoxalin-2(1H)-one derivatives has been successfully performed by using a readily available Cu salt as the catalyst in moderate to excellent yields under mild conditions [e.g, 1-methylquinoxalin-2(1H)-one + Et acetoacetate → I (80%, imine/enamine ≈ 1.46:1) in presence of Cu(OAc)2, TBHP and NaHCO3 in DMSO under Ar]. Owing to the characteristic of handy operation and good functional group tolerance, this protocol affords a convenient access to α-quinoxalinone-substituted β-ketoesters. Preliminary mechanistic investigations show this transformation possibly underwent an unusual ionic pathway. In addition to this study using Ethyl 3-oxopentanoate, there are many other studies that have used Ethyl 3-oxopentanoate(cas: 4949-44-4Quality Control of Ethyl 3-oxopentanoate) was used in this study.
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Quality Control of Ethyl 3-oxopentanoate
Referemce:
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