Yu, Haiyang; Gong, Wen; Mei, Junhao; Qin, Lihao; Piao, Zeyu; You, Deshu; Gu, Wenxian; Jia, Zhongzhi published the artcile< The efficacy of a paeoniflorin-sodium alginate-gelatin skin scaffold for the treatment of diabetic wound: An in vivo study in a rat model>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is paeoniflorin sodium alginate gelatin skin scaffold; diabetes wound healing 3D bioprinting; 3D bio-printing; Diabetes; Paeoniflorin; Skin scaffold; Wound.
To investigate the efficacy of a paeoniflorin-sodium alginate (SA)-gelatin skin scaffold for treating diabetic wound in a rat model. Bioinks were prepared using various percentages of paeoniflorin in the total weight of a solution containing SA and gelatin. Skin scaffolds containing 0%, 1%, 3%, 5%, and 10% paeoniflorin were printed using 3D bioprinting technol. and scaffold microstructure was observed with SEM. Skin scaffolds were then used in rats with diabetic wounds. H&E staining, Masson staining, and immunohistochemichal staining for IL-1β and CD31 were performed on days 7 and 14. All skin scaffolds had a mesh-like structure with uniform pore distribution. Wounds healed well in each group, with the 1% and 3% groups demonstrating the most complete healing. H&E staining showed that skin accessory organs had appeared in each group. On day 7, collagen deposition in the 3% group was higher than in the other groups (P<0.05), and IL-1β infiltration was lower in the 10% group than in the 3% group (P = 0.002). On day 14, IL-1β infiltration was not significantly different between the 10% and 3% groups (P = 0.078). The CD31 level was higher in the 3% group than in the other groups on days 7 and 14 (P<0.05). A 3% paeoniflorin-SA-gelatin skin scaffold promoted the healing of diabetic wounds in rats. This scaffold promoted collagen deposition and microvascular regeneration and demonstrated anti-inflammatory properties, suggesting that this scaffold type could be used to treat diabetic wounds. Biomedicine & Pharmacotherapy published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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