Ye, Chen-Xi; Chen, Shuming; Han, Feng; Xie, Xiulan; Ivlev, Sergei; Houk, K. N.; Meggers, Eric published an article in Angewandte Chemie, International Edition. The title of the article was 《Atroposelective Synthesis of Axially Chiral N-Arylpyrroles by Chiral-at-Rhodium Catalysis》.Application In Synthesis of Methyl 3-oxovalerate The author mentioned the following in the article:
A transformation of fluxional into configurationally stable axially chiral N-arylpyrroles was achieved with a highly atroposelective electrophilic aromatic substitution catalyzed by a chiral-at-metal rhodium Lewis acid. Specifically, N-arylpyrroles were alkylated with N-acryloyl-1H-pyrazole electrophiles in up to 93% yield and with up to >99.5% ee, and follow-up conversions reveal the synthetic utility of this new method [e.g., I + N-acryloyl-1H-pyrazole → II (up to 93% yield, 92% isolated, 99% ee)]. DFT calculations elucidate the origins of the observed excellent atroposelectivity. In addition to this study using Methyl 3-oxovalerate, there are many other studies that have used Methyl 3-oxovalerate(cas: 30414-53-0Application In Synthesis of Methyl 3-oxovalerate) was used in this study.
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Application In Synthesis of Methyl 3-oxovalerate
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