《Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins》 was written by Yamaguchi-Sasaki, Toru; Tokura, Seiken; Ogata, Yuya; Kawaguchi, Takanori; Sugaya, Yutaka; Takahashi, Ryo; Iwakiri, Kanako; Abe-Kumasaka, Tomoko; Yoshida, Ippei; Arikawa, Kaho; Sugiyama, Hiroyuki; Kanuma, Kosuke. Safety of Diethyl 2-methylmalonate And the article was included in ACS Medicinal Chemistry Letters in 2020. The article conveys some information:
A series of macrocyclic pyrazolo[1,5-a]pyrimidine derivatives as respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors were designed and synthesized based on docking studies of acyclic inhibitors. This effort resulted in the discovery of several macrocyclic compounds with low nanomolar to subnanomolar activities against the wild-type RSV F protein A2. In addition, compound I showed a single-digit nanomolar potency against the previously reported drug-resistant mutant D486N. Mol. modeling and computational analyses suggested that I binds to the D486N mutant while maintaining a rigid bioactive conformation via macrocyclization and that it interacts with a hydrophobic cavity of the mutant using a new interaction surface of I. This report describes the rational design of macrocyclic compounds with dual inhibitory activities against wild-type and mutant RSV F proteins. In the part of experimental materials, we found many familiar compounds, such as Diethyl 2-methylmalonate(cas: 609-08-5Safety of Diethyl 2-methylmalonate)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Safety of Diethyl 2-methylmalonate
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