Xiao, Haiyan; Wang, Jing; Saul, Alan; Smith, Sylvia B. published the artcile< Comparison of neuroprotective effects of monomethylfumarate to the sigma 1 receptor ligand (+)-pentazocine in a murine model of retinitis pigmentosa>, Product Details of C19H34O2, the main research area is monomethylfumarate pentazocine retinitis pigmentosa neuroprotection.
Activating the cell survival modulator sigma 1 receptor (Sig1R) delays cone photoreceptor cell loss in Pde6βrd10/J (rd10) mice, a model of retinitis pigmentosa. Beneficial effects are abrogated in rd10 mice lacking NRF2, implicating NRF2 as essential to Sig1R-mediated cone neuroprotection. Here we asked whether activation of NRF2 alone is sufficient to rescue cones in rd10 mice. Expression of antioxidant genes was evaluated in 661W cells and in mouse retinas after treatment with monomethylfumarate (MMF), a potent NRF2 activator. Rd10 mice were administered MMF (50 mg/kg) or the Sig1R ligand (+)-pentazocine (PTZ; 0.5 mg/kg) i.p. (every other day, P14-42). Mice were evaluated for visual acuity (optokinetic tracking response), retinal function (electroretinog.) and architecture (SD-OCT); histol. retinal sections were evaluated morphometrically. MMF treatment increased Nrf2, Nqo1, Cat, Sod1, and Hmox1 expression in vitro and in vivo. Visual acuity of (+)-PTZ-treated rd10 mice was similar to wild-type mice; however, MMF treatment did not alter acuity compared with nontreated rd10 mice. Cone electroretinog. b-wave amplitudes were greater in PTZ-treated than nontreated or MMF-treated rd10 mice. SD-OCT assessment of retinal thickness was greater in (+)-PTZ-treated mice vs. nontreated or MMF-treated rd10 mice. Morphometric assessment of the outer nuclear layer revealed approx. 18 cells/100μm retinal length in (+)-PTZ-treated rd10 mice, but only approx. 10 to 12 cells/100μm in MMF-treated and nontreated rd10 retinas. Activation of NRF2 using MMF, at least at our dosing regimen, is insufficient to attenuate catastrophic photoreceptor damage characteristic of rd10 mice. The data prompt investigation of addnl. mechanisms involved in Sig1R-mediated retinal neuroprotection.
Investigative Ophthalmology & Visual Science published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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