Ulmer, Anna; Brunner, Christoph; Arnold, Andreas M.; Poethig, Alexander; Gulder, Tanja published the artcile< A Fluorination/Aryl Migration/Cyclization Cascade for the Metal-Free Synthesis of Fluoro-Benzoxazepines>, Related Products of 112-63-0, the main research area is fluorobenzoxazepine preparation fluorination aryl migration cyclization cascade; regioselective chemoselective benzoxazepine preparation styrene fluoroiodane compound cascade; 1,2-aryl shift; benzoxazepines; fluorination; hypervalent iodine.
Fluorinated organic mols. are of high interest for many applications across chem. and medical disciplines. Efficient methods for the synthesis of such compounds are thus needed. Within this work, application of the bench-stable cyclic hypervalent iodine(III) fluoro reagent facilitated the development of an efficient, metal-free method for the preparation of the novel class of 4-fluoro-1,3-benzoxazepines starting from readily available styrenes. The efficacy and broad applicability of this concept is demonstrated by the synthesis of 20 structurally diverse congeners in high yields, regio-, and diastereoselectivities. The presented method provides complementary chemoselectivity when compared to the common, com. available electrophilic fluorination reagents, such as selectfluor. First mechanistic investigations with isotopically labeled substrates reveal a complex reaction mechanism, proceeding via an unusual fluorination/1,2-aryl migration/cyclization cascade.
Chemistry – A European Journal published new progress about Aryl alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (styrenes). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics