Related Products of 4248-19-5In 2019 ,《Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products》 was published in Science (Washington, DC, United States). The article was written by Ting, Chi P.; Funk, Michael A.; Halaby, Steve L.; Zhang, Zhengan; Gonen, Tamir; van der Donk, Wilfred A.. The article contains the following contents:
Genome sequencing of environmental bacteria allows identification of biosynthetic gene clusters encoding unusual combinations of enzymes that produce unknown natural products. We identified a pathway in which a ribosomally synthesized small peptide serves as a scaffold for nonribosomal peptide extension and chem. modification. Amino acids are transferred to the carboxy terminus of the peptide through ATP and aminoacyltRNA-dependent chem. that is independent of the ribosome. Oxidative rearrangement, carboxymethylation, and proteolysis of a terminal cysteine yields an amino acid-derived small mol. Microcrystal electron diffraction demonstrates that the resulting product is isosteric to glutamate. We show that a similar peptide extension is used during the biosynthesis of the ammosamides, which are cytotoxic pyrroloquinoline alkaloids. These results suggest an alternative paradigm for biosynthesis of amino acid-derived natural products. In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Related Products of 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Related Products of 4248-19-5
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