《Synthesis of 1,2,3-Triazoles Bearing a 4-Hydroxyisoxazolidine Moiety from 4,5-Unsubstituted 2,3-Dihydroisoxazoles》 was written by Stadaniova, Radka; Sahulcik, Michal; Dohanosova, Jana; Moncol, Jan; Janotka, Lubos; Simonicova, Kristina; Messingerova, Lucia; Fischer, Robert. SDS of cas: 36016-38-3 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:
A synthetic approach towards new 1,2,3-triazoles bearing the 3-hydroxymethylated 4-hydroxyisoxazolidine moiety has been described. The strategy has relied on dihydroxylation and epoxidation reactions of 4,5-unsubstituted 2,3-dihydroisoxazoles, allowing the introduction of the hydroxy group at the isoxazolidine ring in a trans stereoselective manner with respect to the substituent at C-3 carbon atom. The requisite 5-azidoisoxazolidines have been prepared from activated isoxazolidines possessing a good leaving group at C-5 carbon atom by treatment with trimethylsilyl azide and Lewis acid (isoxazolidinyl benzoates) or with sodium azide (chloroisoxazolidines). The 1,2,3-triazole moiety has been synthesized through copper(I)-catalyzed azide-alkyne cycloaddition In addition to this study using N-tert-Butoxycarbonylhydroxylamine, there are many other studies that have used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3SDS of cas: 36016-38-3) was used in this study.
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).SDS of cas: 36016-38-3
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