Seebach, Dieter; Aebi, Johannes; Wasmuth, Daniel published the artcile< Diastereoselective α-alkylation of β-hydroxycarboxylic esters through alkoxide enolates: (+)-diethyl (2S,3R)-3-allyl-2-hydroxysuccinate from (-)-diethyl S-malate (butanedioic acid, 2-hydroxy-3-(2-propenyl)-, diethyl ester, [S-(R,S)])>, Application In Synthesis of 617-55-0, the main research area is diastereoselective alkylation hydroxycarboxylate; alkylation diastereoselective ethyl malate; alkoxide enolate alkylation diastereoselective.
The reaction of di-Et (S)(-)-malate with LiN(CHMe2)2 at -78 to -20° under 100 mm Hg argon pressure, followed by treatment with CH2:CHCH2Br gave 92% u-CH2:CHCH2CH(CO2Et)CH(OH)CO2Et (u-I) and 8% l-I. Similarly prepared were 14 other I analogs.
Organic Syntheses published new progress about Alkylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics