Poulsen, Thomas B’s team published research in Angewandte Chemie, International Edition in 2005-05-06 | 112-63-0

Angewandte Chemie, International Edition published new progress about Mannich reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Poulsen, Thomas B.; Alemparte, Carlos; Saaby, Steen; Bella, Marco; Jorgensen, Karl Anker published the artcile< Direct organocatalytic and highly enantio- and diastereoselective Mannich reactions of α-substituted α-cyanoacetates>, Synthetic Route of 112-63-0, the main research area is Mannich stereoselective cyanoacetate imino ester quinidine catalyst.

Highly functionalized mols. with two contiguous stereocenters are easily accessed in high yield with high enantio- and diastereoselectivity by using the com. available organocatalyst (DHQD)2PYR. The easily removed Boc protecting group in the product is an added value to this method as an important tool in asym. synthesis.

Angewandte Chemie, International Edition published new progress about Mannich reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics