Park, Su Ho; Yoon, Hee Kyoon; Lee, Hyo Won published the artcile< Metal-mediated diastereoselective allylation reaction of chiral α,β-epoxy aldehyde. Part 2>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is homoallylic alc chiral preparation zinc epoxy aldehyde allylation.
A general method for a metal-promoted stereoselective allylation of chiral epoxy aldehydes using methallyl bromide is reported here. The asym. synthesis of chiral 3-[(2S)-3-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-[(4-methoxyphenyl)methoxy]-2-oxiranecarboxaldehyde using (S)-malic acid as starting material was achieved. A subsequent zinc-mediated allylation of this aldehyde provided a homoallylic alc. having anti-configuration as the major product.
Bulletin of the Korean Chemical Society published new progress about Alcohols, homoallylic Role: SPN (Synthetic Preparation), PREP (Preparation) (epoxy, chiral). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics