Marsicano, Vincenzo; Arcadi, Antonio; Chiarini, Marco; Fabrizi, Giancarlo; Goggiamani, Antonella; Iazzetti, Antonia published an article in 2021. The article was titled 《Sequential condensation/biannulation reactions of β-(2-aminophenyl)-α,β-ynones with 1,3-dicarbonyls》, and you may find the article in Organic & Biomolecular Chemistry.Reference of Ethyl 3-oxopentanoate The information in the text is summarized as follows:
A divergent domino condensation/biannulation reaction of β-(2-aminophenyl) α,β-ynones with 1,3-dicarbonyls to construct a polycyclic 4H-pyrano[3,4-c]quinoline core was developed. The p-TsOH·H2O catalyzed reaction of β-(2-aminophenyl) α,β-ynones with β-ketoesters in ethanol proceeded with good to excellent yields to provide a simple and effective method for the synthesis of functionalized 4H-pyrano[3,4-c]quinolinones. Further elaboration of these latter derivatives with an excess of 20% NH4OH in EtOH at 50°C helped to achieve the synthesis of the perlodinine analogs benzo[c][2,7]naphthyridin-4(3H)-one derivatives in high yields. Moreover, the p-TsOH·H2O mediated reaction of β-(2-aminophenyl) α,β-ynones with β-di-ketones led to the formation of a variety of structurally diverse 4H-pyrano[3,4-c]quinoline polycyclic ketals by the incorporation of an alc. solvent mol. in a cascade fashion. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Reference of Ethyl 3-oxopentanoate)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Reference of Ethyl 3-oxopentanoate
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