In 2002,Ladame, Sylvain; Willson, Michele; Perie, Jacques published 《A convenient synthesis of dibenzyl α,α-difluoromethyl-β-ketophosphonates》.European Journal of Organic Chemistry published the findings.Formula: C4H8O3 The information in the text is summarized as follows:
The first synthesis of dibenzyl α,α-difluoro-β-ketophosphonates has been accomplished by an original fluorination reaction, namely addition of the F+ ion to the enolate form of the corresponding dibenzyl β-ketophosphonate. After an easy cleavage of the benzyloxy protecting groups on the phosphorus atom, α-fluoro-β-ketophosphonic acids were subsequently obtained as stable carboxyphosphate mimics. This approach enables α,α-difluoro-β-ketophosphonate moieties to be introduced into multiply functionalized mols., thus making the previously described di-Et phosphonate route no longer relevant. Moreover, study of their stability under neutral and basic conditions showed the importance of the keto-enol equilibrium in the decomposition pathway of these mols. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-hydroxypropanoate(cas: 6149-41-3Formula: C4H8O3)
Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H8O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics