In 2013,Kakadiya, Monika; Parmar, Bharti; Chethan, G. H.; Deka, Satyendra; Saravanan, J.; Mohan, S. published 《Synthesis of some novel triazole heterocyclic derivatives as antibacterial agents》.American Journal of PharmTech Research published the findings.Recommanded Product: Ethyl 2-amino-2-thioxoacetate The information in the text is summarized as follows:
Ethyl-4-(4′-chlorophenyl)-thiazol-2-carboxylate was treatment with hydrazine hydrate to obtain 4-(4′-chlorophenyl)-thiazol-2-carbohydrazide and subsequent reaction with alc. potassium hydroxide and carbon disulfide yielded potassium-[4-(4′-chlorophenyl)-thiazol]-2-dithiocarbazinate . Moreover 4-amino-5-(4′-(4”-chlorophenyl)thiazol-2′-yl)-3-mercapto-4H-1,2,4-triazole was obtained by the reaction of potassium salt of thiazolyl derv. with hydrazine hydrate in water under reflux conditions. Further condensation with substituted aromatic aldehydes generated the corresponding different triazole derivatives The structures of the compounds were confirmed by elemental anal. and spectral anal. Antibacterial activity of the synthesized compounds was evaluated by tube dilution method against two gram pos. and two gram neg. bacteria using ciprofloxacin as standard In the experiment, the researchers used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Recommanded Product: Ethyl 2-amino-2-thioxoacetate)
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Recommanded Product: Ethyl 2-amino-2-thioxoacetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics