Jeon, Hyun Ji; Lee, Wongyu; Seo, Sangwon; Chang, Sukbok published their research in Organic Process Research & Development in 2021. The article was titled 《N-Chloro-N-sodio-carbamates as a Practical Amidating Reagent for Scalable and Sustainable Amidation of Aldehydes under Visible Light》.Product Details of 4248-19-5 The article contains the following contents:
Herein, the scalability and sustainability investigations toward the visible light-mediated amidation of aldehydes with N-chloro-N-sodio-carbamates was described. The practicality credentials of N-chloro-N-sodio-carbamates for their use in multigram scale amidation reactions were proven by scale-up productions and thermogravimetric anal. The described amidation, which was previously hampered in sustainability perspectives by the use of α,α,α-trifluorotoluene solvent, was then improved through re-optimizations using Et acetate as an alternative green solvent. The generality of multigram scale amidations was demonstrated by the conversion of a selected list of aldehydes, in which the corresponding amides I [R1 = n-hexyl, cyclohexyl, Ph, etc.; R2 = CO2t-Bu, CO2Bn] could be isolated in high purity without the need for special purification procedures. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Product Details of 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Product Details of 4248-19-5
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