Quality Control of Methyl 3-oxovalerateOn October 18, 2021 ,《Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones》 was published in Angewandte Chemie, International Edition. The article was written by Hu, Tianjiao; Lueckemeier, Lukas; Daniliuc, Constantin; Glorius, Frank. The article contains the following contents:
The Ru(II)-NHC-catalyzed asym. hydrogenation of 2-quinolones under mild reaction conditions was developed. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones I [R = H, Me; R1 = Me, Bn; R2 = H, Me, Et, i-Pr, Ph; R3 = H; R4 = H, Me, Ph, etc.; R5 = H, OMe, F, etc.; R6 = H, Me; R1R3 = (CH2)3] were obtained in high yields with moderate to excellent enantioselectivities. The reaction provided an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Quality Control of Methyl 3-oxovalerate)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Quality Control of Methyl 3-oxovalerate
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