《Design and Scalable Synthesis of N-Alkylhydroxylamine Reagents for the Direct Iron-Catalyzed Installation of Medicinally Relevant Amines》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Falk, Eric; Makai, Szabolcs; Delcaillau, Tristan; Guertler, Laura; Morandi, Bill. Safety of N-tert-Butoxycarbonylhydroxylamine The article mentions the following:
Secondary and tertiary alkylamines are privileged substance classes that are often found in pharmaceuticals and other biol. active small mols. Herein, the authors report their direct synthesis from alkenes through an aminative difunctionalization reaction enabled by iron catalysis. A family of ten novel hydroxylamine-derived aminating reagents were designed for the installation of several medicinally relevant amine groups, such as methylamine, morpholine and piperazine, through the aminochlorination of alkenes. The method has excellent functional group tolerance and a broad scope of alkenes was converted to the corresponding products, including several drug-like mols. Besides aminochlorination, the installation of other functionalities through aminoazidation, aminohydroxylation and even intramol. carboamination reactions, was demonstrated, further highlighting the broad potential of these new reagents for the discovery of novel amination reactions. The experimental part of the paper was very detailed, including the reaction process of N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Safety of N-tert-Butoxycarbonylhydroxylamine)
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of N-tert-Butoxycarbonylhydroxylamine
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