Easmon, Johnny; Puerstinger, Gerhard; Heinisch, Gottfried; Fiebig, Hans H.; Roth, Thomas; Hofmann, Johann published the artcile< Synthesis, Cytotoxic, and Antitumor Activities of 2-Pyridylhydrazones Derived from 3-Benzoylpyridazines>, Application In Synthesis of 112-63-0, the main research area is pyridylhydrazone preparation anticancer; pyridylhydrazine benzoylpyridazine condensation; 3-Benzoylpyridazine 2′-pyridylhydrazones; Antitumor activity; Colony forming assay; Cytotoxic activity.
A series of 2-pyridylhydrazones derived from phenyl-pyridazin-3-yl-methanones were prepared in search for potential novel antitumor agents. The stereochem. of these compounds was established by means of NMR spectroscopy. Whereas hydrazones derived from 3-benzoylpyridazines (IC50 = 0.99-8.74 μM) inhibited the proliferation of the tumor cell lines tested, the non-fully aromatic 3-benzoylpyridazinone hydrazones (IC50 > 10 μM) turned out to be inactive. Compounds I (R = H, R1 = OMe, IC50 = 0.12 μM) and I (R = OMe, R1 = H, IC50 = 0.18 μM) exert high cytotoxic activities in clonogenic assays involving human tumor cells of different tissue origins. In vivo application of compound I (R = H, R1 = OMe, 300 mg/kg/day) resulted in a 66% reduction in tumor burden.
Archiv der Pharmazie (Weinheim, Germany) published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics