Dajek, Maciej; Pruszczynska, Agnieszka; Konieczny, Krzysztof A.; Kowalczyk, Rafal published the artcile< Cinchona Squaramide-Catalyzed Intermolecular Desymmetrization of 1,3-Diketones Leading to Chiral 1,4-Dihydropyridines>, Category: esters-buliding-blocks, the main research area is cyclic diketone unsaturated ketoester ammonium acetate squaramide catalyst Michael; hexahydroquinoline carboxylate diastereoselective preparation.
Addition of prochiral cyclic 1,3-diketones to Michael acceptors applying bifunctional Cinchona-derived squaramides resulted in chiral adducts with stereoselectivities of up to 99% ee and allowed for desymmetrization of the nucleophile. These labile hemiacetal intermediates were transformed to new 1,4-dihydropyridines with high diastereoselectivities and no erosion of optical purity. Their further oxidation to pyridine followed by Fisher indolization provided chiral pyridine-indoles.
Advanced Synthesis & Catalysis published new progress about Benzopyrans Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics