The author of 《Palladium-Catalyzed Amidation and Amination of (Hetero)aryl Chlorides under Homogeneous Conditions Enabled by a Soluble DBU/NaTFA Dual-Base System》 were Beutner, Gregory L.; Coombs, John R.; Green, Rebecca A.; Inankur, Bahar; Lin, Dong; Qiu, Jun; Roberts, Frederick; Simmons, Eric M.; Wisniewski, Steven R.. And the article was published in Organic Process Research & Development in 2019. Formula: C5H11NO2 The author mentioned the following in the article:
The palladium-catalyzed coupling of aryl and heteroaryl chlorides with primary amides under mild homogeneous reaction conditions is reported. Successful C-N coupling is enabled using a unique “”dual-base”” system consisting of DBU and NaTFA, which serve as proton acceptor and halide scavenger, resp., using low catalyst loadings (0.5 mol %) with readily available, air-stable palladium precatalysts. The DBU/NaTFA system also enables the room-temperature coupling of primary aryl amines with aryl chlorides and is tolerant of a variety of base-sensitive functional groups. In the experimental materials used by the author, we found tert-Butyl carbamate(cas: 4248-19-5Formula: C5H11NO2)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Formula: C5H11NO2
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