Yamamoto, Shuhei; Yoshikawa, Yutaka; Ueda, Eriko; Yamashita, Tetushi; Kajiwara, Naemi; Sakurai, Hiromu; Kojima, Yoshitane published the artcile< Insulinomimetic activity of zinc (II) complexes with halogenated picolinic acids>, Synthetic Route of 112-63-0, the main research area is antidiabetic zinc complex halogenated picolinic acid.
We prepared six new zinc(II) complexes of halogenated picolinic acids with a Zn(N2O2) coordination mode and evaluated for their insulinomimetic activities by in vitro study. By introducing an electron withdrawing halogen groups into the picolinic acid, we prepared bis(4- or 6-chloro picolinato), bis(4-, 5- or 6-iodo picolinato), and bis(6-bromo picolinato)/zinc(II) complexes (Zn(4cpa)2, Zn(6cpa)2, Zn(4ipa)2, Zn(5ipa)2, Zn(6ipa)2, and Zn(6bpa)2, resp.). By in vitro evaluation of the inhibition of free fatty acid (FFA) release from isolated rat adipocytes in the presence of epinephrine, the insulinomimetic activities of Zn(4cpa)2, Zn(6cpa)2, Zn(4ipa)2, Zn(6ipa)2, and Zn(6bpa)2 (IC50 = 0.64, 0.60, 0.77, 0.85, and 0.50 mM, resp.) were higher than that of bis(picolinato)/zinc(II) complex (Zn(pic)2) (IC50 = 1.00 mM) in terms of IC50 value, the 50% inhibition concentrations for the FFA release from rat adipocytes.
Biomedical Research on Trace Elements published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
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