Wu, Dongdong; Lei, Hai; Xie, Xian; Zhou, Liang; Zheng, Peng; Cao, Yi; Zhang, Yan published the artcile< Self-sorting double network hydrogels with photo-definable biochemical cues as artificial synthetic extracellular matrix>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is double network hydrogel extracellular matrix immunofluorescence staining.
In soft connective tissues, the extracellular matrix (ECM) provides spatiotemporally well-defined mech. and chem. cues that regulate the functions of residing cells. However, it remains challenging to replicate these essential features in synthetic biomaterials. Here, we develop a self-sorting double network hydrogel (SDNH) with spatially well-defined bioactive ligands as synthetic ECM. Specifically, the SDNH is made of two peptides that can independently self-assemble into fibers of different microscopic features, mimicking the hierarchical protein assemblies in ECM. Each peptide contains a photo-reactive moiety for orthogonally patterning bioactive mols. (i.e., cyclic arginine-glycine-aspartate (cRGD) and osteogenic growth peptide (OGP)) using UV and visible light. As a proof-of-principle, we demonstrate the engineering of SDNH with spatially separated or colocalized cRGD and OGP mols. to control the response of encapsulated stem cells. Our study represents an important step towards defining the mech. and biochem. cues of synthetic ECM using advanced chem. biol. tools. [graphic not available: see fulltext]
Nano Research published new progress about Cell culture. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics