Romanov-Michailidis, Fedor; Besnard, Celine; Alexakis, Alexandre published the artcile< N-Heterocyclic Carbene-Catalyzed Annulation of α-Cyano-1,4-diketones with Ynals>, Reference of 112-63-0, the main research area is heterocyclic carbene catalyst cyclization cyano diketone ynal; furopyranone stereoselective preparation.
In this paper, the first stereoselective annulation reaction between α-cyano-1,4-diketones and ynals, mediated by catalytic amounts of a triazolium salt precatalyst and cocatalytic amounts of a weak carboxylate base, is disclosed. The title transformation proceeds smoothly under mild reaction conditions and generates three contiguous stereogenic centers, one of which is a quaternary acetal carbon. This reaction tolerates a wide variety of electronically distinct substituents on both reaction partners and affords privileged bicyclic scaffolds, e.g. I, in 61-90% isolated yields and with up to 20:1 diastereomeric preference.
Organic Letters published new progress about Alkynals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics