Petrenko, Daria; Chubarev, Vladimir; Syzrantsev, Nikita; Ismail, Nafeeza; Merkulov, Vadim; Sologova, Susanna; Grigorevskikh, Ekaterina; Smolyarchuk, Elena; Alyautdin, Renad published the artcile< Temozolomide Efficacy and Metabolism: The Implicit Relevance of Nanoscale Delivery Systems †>, Product Details of C19H34O2, the main research area is MTIC; drug delivery systems; glioblastoma; nanocarriers; nanoparticles (NP); temozolomide (TMZ).
The most common primary malignant brain tumors in adults are gliomas. Glioblastoma is the most prevalent and aggressive tumor subtype of glioma. Current standards for the treatment of glioblastoma include a combination of surgical, radiation, and drug therapy methods. The drug therapy currently includes temozolomide (TMZ), an alkylating agent, and bevacizumab, a recombinant monoclonal IgG1 antibody that selectively binds to and inhibits the biol. activity of vascular endothelial growth factor. Supplementation of glioblastoma radiation therapy with TMZ increased patient survival from 12.1 to 14.6 mo. The specificity of TMZ effect on brain tumors is largely determined by special aspects of its pharmacokinetics. TMZ is an orally bioavailable prodrug, which is well absorbed from the gastrointestinal tract and is converted to its active alkylating metabolite 5-(3-Me triazen-1-yl)imidazole-4-carbozamide (MTIC) spontaneously in physiol. condition that does not require hepatic involvement. MTIC produced in the plasma is not able to cross the BBB and is formed locally in the brain. A promising way to increase the effectiveness of TMZ chemotherapy for glioblastoma is to prevent its hydrolysis in peripheral tissues and thereby increase the drug concentration in the brain that nanoscale delivery systems can provide. The review discusses possible ways to increase the efficacy of TMZ using nanocarriers.
Molecules published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics