Farag, Mohamed A.; Fahmy, Sherifa; Choucry, Mouchira A.; Wahdan, Mariam O.; Elsebai, Mahmoud Fahmi published the artcile< Metabolites profiling reveals for antimicrobial compositional differences and action mechanism in the toothbrushing stick ""miswak"" Salvadora persica>, Reference of 112-63-0, the main research area is metabolite profile antimicrobial toothbrush miswak Salvadora benzyl isothiocyanate; Antimicrobial activity; Benzyl isothiocyanate; GC–MS; Metabolomics; S. persica; Solid phase microextraction.
Among many plant species suitable for preparing toothbrushing sticks, miswak (Salvadora persica, family Salvadoraceae) is found the most effective tool for oral hygiene. S. persica possesses antibacterial, antiviral and antifungal effects against oral microbes, mostly due to its benzyl isothiocyanate content. To provide insight into S. persica chem. composition, volatile constituents from roots and stems of S. persica grown in Egypt and Saudi Arabia were profiled using solid-phase microextraction (SPME) coupled to gas chromatog.-mass spectrometry (GC-MS). A total of 21 volatiles were identified with sulfur compounds amounting for the major volatile class. Orthogonal projection to latent structures-discriminant anal. (OPLS-DA) revealed for benzyl isothiocyanate (BITC) enrichment in roots vs. stems. Primary metabolites contributing to S. persica taste viz. sugars and organic acids were profiled using GC-MS with silylation. Polyols (sugars) viz. arabitol, meso-erythritol, and mannitol were found to predominate sugars composition in S. persica stems being most enriched in meso-erythritol. The impact of saliva on S. persica aroma profile was further assessed and revealing for no enhancement in BITC production with salivation, and further not being detected in toothpaste preparation claimed to contain S. persica extract This study provides the most complete profile of volatiles, sugars, and organic acids in S. persica organs and more rationalizing its use as a toothbrush.
Journal of Pharmaceutical and Biomedical Analysis published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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