Dong, Qiang; Wang, Degui; Li, Lanlan; Wang, Jie; Li, Qiao; Duan, Lei; Yin, Hang; Wang, Xiaoqing; Liu, Yang; Yuan, Guoqiang; Pan, Yawen published the artcile< Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy>, Category: esters-buliding-blocks, the main research area is biochanin temozolomide anticancer agent autophagy glioblastoma; AMPK; Autophagy; Biochanin A; Chemosensitivity; Glioblastoma; Molecular docking.
Resistance to temozolomide (TMZ) chemotherapy is the main reason for treatment failure in patients with glioblastoma (GBM). In the present study, we investigated biochanin A (BCA) a potent sensitizer of TMZ in GBM. We observed that BCA significantly enhanced cell sensitivity to TMZ in vitro and in vivo. Mechanistically, the specific chemosensitizing effect of BCA is mediated by autophagy inhibition. Moreover, by performing a mol. docking anal., we demonstrated that BCA interacts with AMPK residues and impairs autophagy by regulating the AMPK/ULK1 pathway. These results suggest that BCA is a potential therapeutic agent that sensitizes GBM to TMZ and provide new insight into its therapeutic potential in chemoresistant GBM.
Molecular Neurobiology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
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